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Beam Therapeutics

Key Facts as at 31.03.2022

Company locationUSA
Size in % of securities1.0%
Size of stake in company0.8%
Market capitalizationUSD 3.9 bn

Sector

Gene editing

Main candidate

BEAM-101

Main indications

Sickle cell disease and beta-thalassemia

About the company

Beam Therapeutics is a biotechnology company focused on developing precision genetic medicines. The company was founded in 2017 and is headquartered in Massachusetts in the US. Beam is working on a new approach to genome engineering termed base editing. Base editors have two principal components that are fused together to form a single protein: (i) a CRISPR protein, bound to a guide RNA, that leverages the established DNA-targeting ability of CRISPR, but modified such that they do not cause a double-stranded break, and (ii) a base editing enzyme, such as deaminase, which carries out the desired chemical modification of the target DNA base. This combination enables the precise targeting and editing of a single base pair of DNA. Base editing is an emerging class of precision genetic medicines creating potential therapeutic options designed to overcome limitations of existing approaches and expand the potential of genetic medicine. Beam is building a portfolio of product candidates in disease areas such as hematology, oncology, liver diseases and CNS diseases. In January 2022, the company announced a collaboration with Pfizer focused on in vivo base editing programs for three targets for rare genetic diseases of the liver, muscle and central nervous system

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